Advances in Molecular Toxicology by James C. Fishbein (Eds.)

By James C. Fishbein (Eds.)

Advances in Molecular Toxicology positive factors the newest advances in the entire subspecialties of the vast sector of molecular toxicology. Toxicology is the research of toxins, and this sequence info the learn of the molecular foundation during which an unlimited array of brokers encountered within the human surroundings and produced through the human physique itself take place themselves as pollutants. now not strictly constrained to documenting those examples, the sequence is additionally concerned about the advanced internet of chemical and organic occasions that supply upward thrust to toxin-induced indicators and sickness. the hot applied sciences which are being harnessed to research and comprehend those occasions can be reviewed via prime employees within the box. Advances in Molecular Toxicology will document development in all features of those speedily evolving molecular features of toxicology with a view towards specific elucidation of either growth at the molecular point and on advances in technological ways hired. * state-of-the-art reports through prime staff within the self-discipline. * In-depth dissection of molecular facets of curiosity to a large variety of scientists, physicians and any scholar within the allied disciplines. * innovative functions of technological thoughts in chemistry, biochemistry and molecular drugs.

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R. A. Doupnik, Bronchial responsiveness and inflammation in guinea pigs exposed to acrolein, J. Appl. Physiol. 66 (1989) 171–178. R. B. D. P. C. Williams, Protective role for neuropeptides in acute pulmonary response to acrolein in guinea pigs, J. Appl. Physiol. 75 (1993) 2456–2465. Invited Review 35 [126] E. Andre, B. Campi, S. Materazzi, M. Trevisani, S. Amadesi, D. Massi, C. Creminon, N. Vaksman, R. Nassini, M. G. P. W. Bunnett, P. Geppetti, R. Patacchini, Cigarette smoke-induced neurogenic inflammation is mediated by a,b-unsaturated aldehydes and the TRPA1 receptor in rodents, J.

Otterbein, R. Song, S. Hayashi, Z. J. C. M. C. G. C. M. Choi, Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease, Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 14895–14900. R. G. R. Hoidal, Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells, Am. J. Respir. Cell Mol. Biol. 35 (2006) 314–319. [16] W. Ning, Y. Dong, J. Sun, C. A. A. M. Choi, Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts, Am.

5. Cell death pathways As with other cellular responses to acrolein, the cell death pathways it initiates in cells of pulmonary origin have been most commonly defined in vitro. In cells of nonpulmonary origin, acrolein has been shown to induce both necrotic and apoptotic forms of cell death, with evidence presented to suggest the latter proceeds via both mitochondrial (intrinsic) and deathreceptor-mediated (extrinsic) pathways [41,115–117]. In recent work conducted in A549 lung cells, acrolein initiated cellular changes that are characteristic of both early- and late-stage intrinsic apoptosis, including Bax relocation to the mitochondria, collapse in the mitochondrial membrane potential, cytochrome c release, activation of caspases-3 and -7, and redistribution of apoptosis-inducing factor-1 to the nucleus [118].

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